
Aline Kegler
Federal University of Santa Maria, BrazilTitle: The cognitive dysfunction in epilepsy patients
Abstract
Epilepsy is a brain disease that affects around 50
million people worldwide. It is characterized by
recurrent seizures, which are brief episodes of
involuntary movement that may involve a part
(partial) or entire body (generalized) and are
sometimes accompanied by loss of consciousness
and control of bowel or bladder function. Some
epilepsy patients may be at a higher risk of
developing dementia, while individuals with some
forms of dementia, particularly Alzheimer’s
disease and vascular dementia, are at significantly
higher risk of developing epilepsy. Consistent with
this emerging view, epidemiological findings
reveal that epilepsy and Alzheimer’s disease share
common risk factors.
In the present study, a neuropsychological
evaluation (battery of cognitive tests) was held
with two groups: epilepsy and control group.
The results demonstrated a worse performance
related to cognitive impairment, including praxis,
perception, attention, language, executive
functions, long-term semantic memory, short-term
visual memory, and total memory in epilepsy group
when compared to control group. Furthermore,
inflammatory biomarkers (TNF-?, IL-1? and IL-6)
are also increase in epilepsy group (blood sample)
suggesting correlation to its damage.
This study supports the evidence of a
distinct neuropsychological profile in epilepsy
patients. Furthermore, our results suggests a link
between inflammatory and cognitive dysfunction
in patients with epilepsy
Biography
Completed doctoral studies at Federal University
of SantaMaria-Brazil. Neurological disorders,
biochemistry, neurology and pharmacology are the
fields of research.Some articles published at
respected journals such as Gene, Biomed Research
International, Progress in Neuropsychopharmacology & Biological Psychiatry.
Oral presentation at the 1
st Congress of The
European Academy of Neurology, Berlin-DE.
Speaker at Geriatrics Congress and Alzheimer
(2021). Guest speaker at 27th
International
Conference on Neurology: Neurochemistry,
Neuropharmacology and Neurosciences (Canada,
March 2022)