Fred MaCognivue, USA
Title: Superior Test-Retest Reliability of Cognitive Assessment with Cognivue® vs Slums During an 18-Month Longitudinal Study
Chronic sleep deprivation has been associated with cognitive impairment in multiple studies. Cognivue is an FDA-cleared computerized testing device and it’s a tool that provides adaptive psychophysical evaluation of cognitive functions. A reliable objective method to evaluate cognitive functions in patients with sleep disorders could be helpful to optimize long-term treatment. In an FDA-regulated study for clearance, Cognivue demonstrated good agreement with St. Louis University Mental Status, or SLUMS, and other neuropsychological tests, and superior test re-test reliability compared to SLUMS across 2 sessions, 1 to 2 weeks apart. This poster presents findings from a longitudinal study of Cognivue. In this analysis, 238 subjects from the FDA-regulated study for clearance enrolled in the longitudinal study. The subjects underwent testing with Cognivue and SLUMS at 3 sessions over 18 months. An analysis of rank linear regression test-retest reliability was performed for both tests. Among these 238 patients, Cognivue demonstrated similar linear regression scores across comparisons. For test sessions 1 and 2, Cognivue’s regression fit was 0.76. For test sessions 1 and 3, the regression fit was 0.72. For test sessions 1 and 4, the regression fit was 0.73. The SLUMS test demonstrated greater variability in regression scores across test sessions. The regression fit scores for SLUMS for test sessions 1 and 2; 1 and 3; and 1 and 4 were 0.63, 0.43, and 0.64, respectively. In conclusion, Cognivue demonstrated maintained superior test re-test reliability compared to SLUMS over a period of 18 months after the FDA-regulated study for clearance. With that, Cognivue could be beneficial in detecting early stages of multi-domain cognitive impairment in patients with sleep disorders, providing an opportunity for early intervention strategies and follow-up over time to improve patient outcomes.